Greater Cholesterol lowering increases the risk of death

Dr. Malcolm Kendrick

Sorry to get distracted from my series on what causes heart disease, yet again. However, I felt the need to blog about this article published in the BMJ on the 12th April 2016.

A group of researchers went back through the data from the Minnesota Coronary Experiment run between 1966 and 1973 in the US – on many thousands of participants. They were, in part stimulated to do this because they had previously looked at the Sydney Diet Heart Study 1966 – 73. In their own words:

‘Our recovery and 2013 publication of previously unpublished data from the Sydney Diet Heart Study (SDHS, 1966-73) belatedly showed that replacement of saturated fat with vegetable oil rich in linoleic acid (a polyunsaturated fat) significantly increased the risks of death from coronary heart disease and all causes, despite lowering serum cholesterol. Our recovery of unpublished documents and raw data from another diet-heart…

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