What causes heart disease part XVIII

Dr. Malcolm Kendrick

Viagra

For those who have read my endless series of blogs on cardiovascular disease, you may know exactly where I am going at this point.

Some time ago, Pfizer were developing a drug to treat angina. It blocked an enzyme called phosphodiesterase type-5. [Although I believe that its exact mechanism of action was not known at first]. To put it another way, this drug was a phosphodiesterase type-5 inhibitor (PDE5i).

The moment Pfizer found out what enzyme this drug blocked, they tried to patent the pathway that blocked this enzyme. Pharmaceutical companies trying to patent biological pathways. Perhaps I should try to patent the Krebs cycle, and charge everyone on the planet for having such a thing. Kerchingggg!

‘The U.S. patent office appears to have granted Pfizer a patent covering any drug that blocks this enzyme, meaning that it can sue all of its potential competitors.’1

Luckily, this…

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Young woman who committed suicide was called ‘a f****** waste of space’ by mental health worker

Politics and Insights

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Suicidal Hannah Groves did not get the support and care she needed

The  Mirror reports: “In the UK the number of ­women taking their own lives has grown steadily since 2011. Mental health issues make up 23 per cent of those with health problems making contact with the NHS. But mental health provision has received only 13 per cent of the overall funding. Since 2011 the number of beds for mental health patients has fallen by 8 per cent.”

Last year female suicides hit a ten year high.  In 2015 – 2016, only 55% of mental health trusts reported increases to budgets since 2012, when “parity of esteem” with physical health was promised by the government.

Last year, a leaked report by a government taskforce painted a bleak picture of England’s mental health services, revealing that the number of people killing themselves was soaring, three-quarters of those with psychiatric conditions…

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Who’s Paying Amnesty Int’l to Lie about Syria?*

Hwaairfan's Blog

Who’s Paying Amnesty Int’l to Lie about Syria?*

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By Tim Hayward

Most of us living outside Syria know very little of the country or its recent history. What we think we know comes via the media. Information that comes with the endorsement of an organisation like Amnesty International we may tend to assume is reliable. Certainly, I always trusted Amnesty International implicitly, believing I understood and shared its moral commitments.

As a decades-long supporter, I never thought to check the reliability of its reporting. Only on seeing the organisation last year relaying messages from the infamous White Helmets did questions arise for me. Having since discovered a problem about the witness testimonies provided by Doctors Without Borders (MSF), I felt a need to look more closely at Amnesty International’s reporting. Amnesty had been influential in forming public moral judgements about the rights and wrongs of the war in Syria.

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Vitamin C – an update

Dr. Malcolm Kendrick

Of course, I am always – ahem – ahead of my time, but I just noted this study that came out very recently. It demonstrates that if you give Vitamin C (along with hydrocortisone and thiamine) for just over two days in patients admitted with sepsis (blood poisoning) the mortality rate falls from 40% to 8.5%. The mortality rate in low income countries is normally around 60%.

Now, this was a small study, but it seems robust. It represents an almost five-fold reduction in mortality, but I think it provides some pretty strong support for the benefits of vitamin C. The conclusions of the study, repeated below were that.

‘Our results suggest that the early use of intravenous vitamin C, together with corticosteroids and thiamine may prove to be effective in preventing progressive organ dysfunction including acute kidney injury and reducing the mortality of patients with severe sepsis and septic…

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